Inoa:γ- waikawa aminobutyric（GABA）

Helu CAS:56-12-2

Nā huaʻōlelo like4-Awaikawa minobutyric; waikawa butyric ammonia;ʻAkika Pipecolic.

1. Pono ka mana o GABA ma ka hānai holoholona e mau loa i loko o kekahi manawa. Pili loa ka lawe ʻana i ka meaʻai i ka hana hana o nā holoholona a me nā manu. Ma ke ʻano he hana paʻakikī, hoʻomalu nui ʻia ka hānai ʻana e ka ʻōnaehana nerve waena. ʻO ke kikowaena māʻona (Ventromedial nucleus o ka hypothalamus) a me ke kikowaena hānai (lateral hypothalamus area) nā mea hoʻoponopono holoholona.

Hiki i ke kikowaena kumu o ka ʻai GABA ke hoʻoulu i ka hānai holoholona ma ke kāohi ʻana i ka hana o ke kikowaena māʻona, e hoʻonui ana i ka hiki ke hānai holoholona. Ua hōʻike ʻia nā haʻawina he nui e hiki i ka hoʻokomo ʻana i kahi pae nui o GABA i loko o nā wahi lolo like ʻole o nā holoholona ke hoʻolaha nui i ka hānai holoholona a loaʻa ka hopena e pili ana i ka nui. ʻO ka hoʻohui ʻana i ka GABA i ka ʻai kumu o nā puaʻa momona hiki ke hoʻonui nui i ka ʻai ʻana i ka puaʻa, hoʻonui i ka loaʻa ʻana o ke kaumaha, a ʻaʻole e hōʻemi i ka hoʻohana ʻana i ka protein hānai.

2. Ka hopena o GABA ma ka ʻōnaehana hoʻoheheʻe gastrointestinal a me ka ʻōnaehana Endocrine Ma ke ʻano he neurotransmitter a modulator paha, he kuleana nui ko GABA i loko o ka ʻōnaehana nerve peripheral Autonomic o nā vertebrates.

3. Ka hopena o GABA ma ka neʻe ʻana o ka ʻōpū. Loaʻa nui ka GABA ma ke ala gastrointestinal, a aia nā olonā nerve immunoreactive GABA a i ʻole nā ​​​​​​kelepona nerve maikaʻi i loko o ka ʻōnaehana nerve a me ka membrane o ke ala gastrointestinal mammalian, ua hoʻolaha pū ʻia nā pūnaewele endocrine GABA ma ka epithelium o ka mucosa Gastric. Loaʻa iā GABA kahi hopena hoʻoponopono i nā pūnaewele ʻiʻo laumania gastrointestinal, nā pūnaewele endocrine a me nā pūnaewele non endocrine. Loaʻa i ka GABA Exogenous kahi hopena inhibitory koʻikoʻi ma nā ʻāpana ʻōpū i hoʻokaʻawale ʻia o nā ʻiole, kahi i hōʻike ʻia i ka hoʻomaha a me ka hoʻemi ʻana o ka amplitude contraction o nā ʻāpana ʻōpū i hoʻokaʻawale ʻia. ʻO kēia ʻano hana inhibitory o GABA ma o ka pale ʻana i nā ʻōnaehana cholinergic a/a i ʻole non cholinergic o ka ʻōpū, Hana me ka ʻole o kahi ʻōnaehana adrenergic; Hiki iā ia ke hoʻopaʻa kūʻokoʻa i ka mea loaʻa GABA pili ma nā pūnaewele ʻiʻo laumania o ka ʻōpū.

4. Hoʻoponopono ʻo GABA i ka metabolism holoholona. Hiki i ka GABA ke loaʻa nā hopena he nui i loko o ka ʻōnaehana gastrointestinal ma ke ʻano he hormone kūloko, e like me kekahi mau glands a me nā hormones endocrine. Ma lalo o nā kūlana in vitro, hiki i ka GABA ke hoʻoulu i ka huna ʻana o ka hormone ulu ma ka hoʻoulu ʻana i ka mea loaʻa GABA i loko o ka ʻōpū. Hiki i ka hormone ulu holoholona ke hoʻolaha i ka synthesis o kekahi mau peptides i loko o ke ake (e like me IGF-1), hoʻonui i ka metabolic rate o nā cell muscle, hoʻonui i ka ulu ʻana a me ka hoʻololi ʻana i ka hānai o nā holoholona, ​​​​I ka manawa like, ua hoʻololi pū ia i ka hoʻolaha ʻana o nā meaʻai hānai i loko o ke kino holoholona; Hiki ke kuhi ʻia e pili ana ka hopena hoʻoulu ulu o GABA i kona hoʻoponopono ʻana i ka hana hormone ulu ma ka hoʻopilikia ʻana i ka hana o ka ʻōnaehana Endocrine nerve.