Pono nā koho ʻē aʻe i nā lāʻau antibiotic ma muli o ke pāpā ʻia ʻana o ka hoʻohana ʻana i kēia mau lāʻau lapaʻau ma ke ʻano he mea hoʻoulu ulu i ka hana holoholona meaʻai. Me he mea lā he kuleana ko Tributyrin i ka hoʻomaikaʻi ʻana i ka hana ulu ʻana i nā puaʻa, ʻoiai me nā pae like ʻole o ka pono.

A hiki i kēia manawa, ʻaʻole nui ka ʻike e pili ana i kona hopena i ka haku mele ʻana o ka microbiota ʻōpū. Ma kēia haʻawina, ua noiʻi mākou i nā loli o ka microbiota ʻōpū o nā puaʻa e loaʻa ana, i ka wā e weaning ai, 0.2% tributyrin i hoʻohui ʻia i kā lākou ʻai kumu.

Loaʻa i ka hui Tributyrin kahi hiki ke hoʻonui ʻia no ka metabolism ikehu a me kahi hiki ke hoʻemi ʻia no ka metabolism carbohydrate. I ka hopena, ua hōʻike kā mākou mau hopena hiki i ka tributyrin ke hoʻoulu i nā loli i nā kaiāulu microbial gut, hiki ke kōkua i ka hoʻomaikaʻi ʻana i ka hana holoholona ma hope o ka weaning.

Nā hopena o Tributyrin ma nā hoʻololi o ka Gut Microbiota e pili ana i ka hana o nā puaʻa weaning

Nā Palena Huahana

ʻO Tributyrin (inoa pū kekahi ʻo Glyceryl tributyrate; Glycerol tributyrate; Glycery tributyrate; propane-1,2,3-triyl tributanoate), he ʻano ester waikawa momona kaulahao pōkole.

CAS RN: 60-01-5

EINECS Helu: 200-451-5

Haʻilula: C15H26O6

FW: 302.36

ʻAno: He wai ʻaila keʻokeʻo a melemele me kahi ʻala momona iki.

Ka hoʻoheheʻe ʻia: hiki ke hoʻoheheʻe ʻia i loko o ka ethanol, chloroform a me ka ether, ʻaneʻane hiki ʻole ke hoʻoheheʻe ʻia i ka wai (0.010%).

Ola Papa: 24 Mahina

Pūʻolo: 25KG/ ʻEke

Mālama: Sila ʻia ma nā wahi maloʻo a me nā wahi ea

ʻO TributyrinHe triglyceride ia e loaʻa ana ʻekolu mau molekala butyrate i hoʻohui ʻia i ka glycerol, hoʻonui i ka nui o ka butyrate ma hope o ka hydrolyzation e nā lipases pancreatic.

Nā ʻano o Tributyrin
Ka hanauna hou o ka butyrate-glycerol ester o ka waikawa butyric.
100% pale ʻōpū.
ʻAʻole pono e uhi ʻia nā waikawa butyric i loko o ka ʻōpū liʻiliʻi.
ʻIke maoli ʻia i loko o ka waiū a me ka meli.

Hoʻohālikelike ma waena o ka paʻakai Tributyrin a me Butyrate

ʻO ka hapalua ola o ka waikawa butyric he 6 mau minuke. He paʻakikī ke hiki aku i ka butyrate i nā ʻiʻo a me nā ʻōkana ʻē aʻe ma waho o ka ʻōpū i hāʻawi ʻia ma ke ʻano o ka waikawa butyric a i ʻole butyrate. Eia nō naʻe, ʻo ka hapalua ola o ka tributyrin he 40 mau minuke, a hiki ke mālama ʻia ka nui o ka butyrate ma luna o 0.1mM no 0.5-4h ma ka waha.

ʻAno hana a me nā hiʻohiʻona

Mea Hoʻolako Ikehu

E like me ka mea i ʻike nui ʻia, ʻo ka waikawa butyric kahi waikawa momona kaulahao pōkole ʻo ia ke kumu ikehu nui o nā pūnaewele epithelial intestinal. ʻOi aku ma mua o 70% o ka ikehu no ka ulu ʻana o nā pūnaewele epithelial intestinal i hāʻawi ʻia e ka waikawa butyric. Eia nō naʻe, hāʻawi ka tributyrin i ka waiwai nui loa o ka waikawa butyric e hoʻokuʻu ana i ka ʻōpū i hoʻohālikelike ʻia me nā huahana butyrate ʻē aʻe.

Ka palekana o ka ʻōpū

►Hoʻoulu ʻo Tributyrin i ka hoʻonui ʻana a me ka hoʻokaʻawale ʻana o nā pūnaewele epithelial mucosal intestinal, hoʻoponopono i ka mucosa i hōʻino ʻia, a hoʻonui i ka ʻili no ka omo ʻana i nā meaola.

►Hoʻoulu ʻo Tributyrin i ka hōʻike ʻana o nā protein tight junction i loko o ka ʻōpū, mālama i nā hui paʻa ma waena o nā cell, pale i nā macromolecules e like me nā bacteria a me nā mea ʻawahia mai ke komo ʻana i ke kino, a mālama i ka hana pale kino o ka ʻōpū.

►Hoʻoulu ʻo Tributyrin i ka hoʻokuʻu ʻana o ka mucin (Muc) a hoʻoikaika i ka hana pale kemika o ka ʻōpū.

Hoʻomaikaʻi ʻia ka helu ola

Hiki i ka Tributyrin ke hoʻoulu i ka hana ʻana o ka hemoglobin, hoʻomaikaʻi i ka hiki ke lawe i ka oxygen, hoʻoikaika i ka ʻōnaehana kākoʻo ola endogenous, a hiki iā ia ke hoʻomaikaʻi i ka hana o ka mitochondria a paipai i ka hana ʻana o ATP, ka mea ikehu e hoʻokele i ka hana ola, i mea e hoʻomaikaʻi ai i ka nui o ke ola o nā holoholona.

Anti-Inflammatory a me Antibacteria

►Ma ke kāohi ʻana i ka hana o NF-Kb, TNF-α a me TLR, hiki iā Tributyrin ke hōʻoluʻolu i ka hōʻino mumū.

►Hoʻolaha ʻo Tributyrin i ka hōʻike ʻana o nā peptides pale endogenous, hiki ke pale aku i nā pathogen a me nā virus ma ke ʻano ākea.