DMPT, CAS NO.: 4337-33-1. ʻO ka mea maikaʻi loamea hoʻowalewale waii kēia manawa!

DMPTʻike ʻia ʻo dimethyl-β-propiothetin, aia ma ka limu a me nā mea kanu kiʻekiʻe halophytic. Loaʻa iā DMPT kahi hopena hoʻolaha i ka metabolism meaʻai o nā mammals, nā moa, a me nā holoholona wai (iʻa a me ka ʻōpae). ʻO DMPT ka mea me ka hopena lure ikaika loa ma nā holoholona wai ma waena o nā hui i ʻike ʻia e loaʻa ana (CH) a me nā hui S.

1. Kumu o DMPT

ʻO ka dimethyl sulfide (DMS) i hana ʻia e Polysipho - nia fastigata mai kaDMPT, he mea hāʻawi methyl kūpono hoʻi i loko o ka algae, a ʻo ka mea hoʻoponopono osmotic nui o ka algae a me ka mea kanu mudflat ʻo Spartina angelica ʻo DMPT nō hoʻi. ʻOkoʻa ka nui o ka DMPT ma waena o nā ʻano limu like ʻole, a ʻokoʻa hoʻi ka nui o ka limu like i nā kau like ʻole. Hiki i ka DMPT ke hoʻolalelale nui i ka hānai ʻana a me ka ulu ʻana o nā iʻa wai maʻemaʻe like ʻole. He ʻokoʻa ka hopena hoʻoulu hānai o DMPT mai nā mea ʻē aʻe e like me nā waikawa L-amino a i ʻole nā ​​​​nucleotides, a he hopena hānai a me ka ulu ʻana ma aneane nā holoholona wai āpau.

2.1 Nā Ligands Kūpono ma ke ʻano he mau mea loaʻa ʻono

ʻAʻohe mea i loaʻa i ka noiʻi ʻana e pili ana i nā mea loaʻa i loko o nā ʻōpū sensory kemika iʻa e hiki ke launa pū me nā hui S (CH). Mai nā hopena hoʻokolohua hana e kū nei, hiki ke kālailai ʻia he mau mea loaʻa ʻono ko nā iʻa e hiki ke launa pū me nā hui kaumaha molekala haʻahaʻa e loaʻa ana nā hui (CH), N-, a me (CH2) 2S-.

2.2 Ma ke ʻano he mea hāʻawi methyl

ʻO nā hui (CH) a me S ma kaDMPTʻO nā molekala nā kumu o nā hui methyl e pono ai no ka metabolism meaʻai holoholona. Aia ʻelua ʻano methyltransferases (EC2.1.1.3 a me EC2.1.1.5) i loko o ke akepaʻa holoholona i hoʻohana ʻia e nā holoholona (CH) a me S.

Ua ʻike ʻia ua piʻi ka nui o ka DMPT a me ka nui o ka hoʻokuʻu ʻia ʻana o DMS i loko o nā hunaola limu me ka piʻi ʻana o ka paʻakai i loko o ka mea kanu o ka limu i kanu ʻia (Hymenonas carterae).

DMPTua hoʻonui ʻia i loko o nā pūnaewele o nā phytoplankton he nui, algae, a me nā mollusks symbiotic e like me nā clams a me nā corals, a me nā kino krill a me nā iʻa. Ua hōʻoia ʻo Iida et al. (1986) ua pili pono ka ʻike o DMPT a me ka hana ʻana o DMS i loko o ka iʻa me ka ʻike DMPT i kā lākou meaʻai, e hōʻike ana ua hele mai ka laiki DMPT i nā holoholona mai ka maunu a komo i loko o ke kino holoholona kanaka ma o ke kaulahao meaʻai i loko o nā kaiaola kai. Hiki i nā Algae ke synthesize i ka DMPT a hōʻiliʻili iā ia ma nā pae kiʻekiʻe (3-5 mmol/L) i loko o ke kino. ʻO ka DMPT i loko o ka iʻa a me nā mollusks kokoke i ko lākou mau pae i ka meaʻai, a ʻo ka nui o DMPT e hōʻike ana i kahi ʻano emi i ke ʻano o ka algae (1 mmol/L), mollusks (0.1 mmol/L), a me ka iʻa (0.01 mmol/L).

ʻO ke ʻano hana kino oDMPTHana

I nā makahiki i hala iho nei, ua ʻike ʻia ka noiʻi he hopena hoʻolaha ko DMPT i ke ʻano hānai a me ka ulu ʻana o nā iʻa kai a me nā iʻa wai maʻemaʻe like ʻole, nā crustaceans, a me nā iʻa paʻa, hiki ke hoʻomaikaʻi i ko lākou hiki ke pale i ke kaumaha a me ka hoʻoikaika kino, a hoʻohui i nā enzymes koʻikoʻi o ka methyl hui haʻahaʻa i ka meaʻai. Ma ka hoʻohana ʻana i ke akepaʻa o ka iʻa bream ma ke ʻano he mea hoʻokolohua a me nā hui like ʻole e loaʻa ana nā hui (CH) a me S - ma ke ʻano he substrates, ua ʻike ʻia ʻo E C.2.1.1.3 a me E ʻoi aku ka kiʻekiʻe o ka hana enzyme ke hoʻohana ʻia ʻo DMPT ma ke ʻano he substrate.

3. Nā hopena meaʻai o DMPT i nā holoholona wai

Ua hoʻohana ʻia he iwakālua mau hui organik kaumaha molekala haʻahaʻa e loaʻa ana nā hui (CH) a me S no ke ʻano nahu a me nā hoʻokolohua electrophysiological ma ka wai kai a me nā iʻa wai maʻemaʻe. Ua ʻike ʻia ʻo DMPT ka hopena hoʻolaha ikaika loa i ke ʻano nahu o ʻekolu ʻano iʻa, me ka tuna wai maʻemaʻe, ka carp, a me ka carp crucian ʻeleʻele (Carassius auratus cuviera). Ua hoʻolaha nui hoʻi ia i ke ʻano hānai o ka unahi maoli o ka wai kai (Pagrus major) a me nā unahi ʻelima (Seriola quinquera diata).

E hoʻohui i ka DMPT a me nā hui sulfur ʻē aʻe ma kahi nui o 1.0mmol/L. i loko o nā ʻano meaʻai hoʻokolohua like ʻole, a hoʻololi i ka hui kaohi me ka wai i hoʻoheheʻe ʻia e hana i nā hoʻokolohua pane hānai ma ka crucian carp. Ua hōʻike nā hopena i nā hui ʻehā mua o nā hoʻokolohua, he awelika o 126 mau alapine nahu kiʻekiʻe aʻe o ka hui DMPT ma mua o ka hui kaohi; I ka lua o ka hoʻokolohua 5-hui, ʻoi aku ka kiʻekiʻe o ka hui DMPT ma mua o 262.6 mau manawa ma mua o ka hui kaohi. I loko o kahi hoʻokolohua hoʻohālikelike me ka glutamine, ua ʻike ʻia ma kahi nui o 1.0mmol/L.