ʻO ka Sodium Butyrate a i ʻole tributyrin'ʻo wai ka mea e koho ai'?

Ua ʻike nui ʻia he kumu ikehu koʻikoʻi ka waikawa butyric no nā pūnaewele colonic. Eia kekahi, ʻo ia ke kumu wahie makemake nui ʻia a hāʻawi i ka 70% o kā lākou pono ikehu holoʻokoʻa. Eia nō naʻe, aia he 2 mau ʻano e koho ai. Hāʻawi kēia ʻatikala i kahi hoʻohālikelike o nā mea ʻelua, e kōkua ana i ka pane ʻana i ka nīnau 'ʻo wai ka mea e koho ai'?

Ua aʻo nui ʻia ka hoʻohana ʻana o nā butyrates ma ke ʻano he mea hoʻohui hānai a ua hoʻohana ʻia i ka mahiʻai holoholona no kekahi mau makahiki he ʻumi, ua hoʻohana mua ʻia i nā keiki bipi e hoʻoulu i ka ulu mua ʻana o ka rumen ma mua o ka loaʻa ʻana o ka hoʻohana ʻana i ka puaʻa a me ka moa.

Ua hōʻike ʻia nā mea hoʻohui butyrate e hoʻomaikaʻi i ka loaʻa ʻana o ke kaumaha o ke kino (BWG) a me nā helu hoʻololi hānai (FCR), hoʻemi i ka make a hoʻemi i ka hopena o nā maʻi e pili ana i ka ʻōpū.

ʻO nā kumu i loaʻa pinepine ʻia o ka waikawa butyric no ka hānai holoholona e hele mai ana i ʻelua ʻano:

1. Ma ke ʻano he paʻakai (ʻo ia hoʻi ʻo Sodium butyrate) a i ʻole
2. Ma ke ʻano o ka triglyceride (ʻo ia hoʻi ʻo Tributyrin).

A laila hiki mai ka nīnau aʻe -ʻO wai kaʻu e koho ai?Hāʻawi kēia ʻatikala i kahi hoʻohālikelike ʻaoʻao o nā mea ʻelua.

Kaʻina hana

Sodium butyrate:Hana ʻia ma o kahi hopena waikawa-kumu e hana i ka paʻakai me kahi kiko heheʻe kiʻekiʻe.

NaOH+C4 H8 O2=C4 H7 COONa+H2O

(Sodium Hydroxide+Butyric Acid = Sodium Butyrate+Wai)

ʻO Tributyrin:Hana ʻia ma o ka esterification kahi i hoʻopili ʻia ai ka 3 butyric acid i kahi glycerol e hana i ka tributyrin. He haʻahaʻa ka wahi heheʻe o Tributyrin.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(Glycerol+Butyric Acid = Tributyrin + Wai)

ʻO wai ka mea e hāʻawi ana i ka waikawa butyric i ʻoi aku ka nui no kēlā me kēia kg o ka huahana?

MaiPapa 1, ʻike mākou i ka nui o ka waikawa butyric i loko o nā huahana like ʻole. Eia nō naʻe, pono mākou e noʻonoʻo i ke ʻano o ka hoʻokuʻu ʻana o kēia mau huahana i ka waikawa butyric i loko o nā ʻōpū. ʻOiai he paʻakai ka sodium butyrate, e hoʻoheheʻe koke ia i ka wai e hoʻokuʻu ana i ka butyrate, no laila hiki iā mākou ke manaʻo e hoʻokuʻu ʻia ka 100% o ka butyrate mai ka sodium butyrate ke hoʻoheheʻe ʻia. ʻOiai e hoʻokaʻawale koke ʻia ka sodium butyrate, ʻo nā ʻano i pale ʻia (ʻo ia hoʻi ka micro-encapsulation) o ka sodium butyrate e kōkua iā ia e hoʻokō i ka hoʻokuʻu lohi mau o ka butyrate ma loko o nā ʻōpū a hiki i ke kolona.

ʻO Tributyrin he triacylglyceride (TAG) maoli nō, he ester ia i loaʻa mai ka glycerol a me 3 mau momona momona. Pono ʻo Tributyrin i ka lipase e hoʻokuʻu i ka butyrate i hoʻopili ʻia i ka glycerol. ʻOiai aia i loko o 1 tributyrin he 3 butyrate, ʻaʻole i hōʻoia ʻia e hoʻokuʻu ʻia nā 3 butyrate āpau. ʻO kēia no ka mea he regioselective ka lipase. Hiki iā ia ke hydrolyze i nā triacylglycerides ma R1 a me R3, ʻo R2 wale nō, a i ʻole non-specically. Loaʻa iā Lipase ka substrate specificity ma ka hiki i ka enzyme ke hoʻokaʻawale ma waena o nā kaulahao acyl i hoʻopili ʻia i ka glycerol a me ka ʻoki ʻana i kekahi mau ʻano. ʻOiai ʻo tributyrin e koi ana i ka lipase e hoʻokuʻu i kāna butyrate, aia paha he hoʻokūkū ma waena o tributyrin a me nā TAG ʻē aʻe no ka lipase.

E hoʻopilikia anei ka sodium butyrate a me ka tributyrin i ka ʻai ʻana o ka meaʻai?

He ʻala ʻino ko ka sodium butyrate ʻaʻole ia he ʻoluʻolu ʻole no nā kānaka akā makemake ʻia e nā mammals. ʻO ka sodium butyrate ka 3.6-3.8% o ka momona waiū i loko o ka waiū umauma, no laila, hiki ke hana ma ke ʻano he mea hoʻowalewale hānai e hoʻoulu ai i nā ʻano ola kūlohelohe o nā mammals (Papa 2). Eia nō naʻe, no ka hōʻoia ʻana i ka hoʻokuʻu lohi ʻana i loko o nā ʻōpū, hoʻopili pinepine ʻia ka sodium butyrate me kahi uhi matrix momona (ʻo ia hoʻi ka Palm stearin). Kōkua pū kēia i ka hōʻemi ʻana i ke ʻala pilau o ka sodium butyrate.

Ma ka ʻaoʻao ʻē aʻe, ʻaʻohe ʻala o Tributyrin akā he ʻono astringent kona (Papa 2). ʻO ka hoʻohui ʻana i nā nui he nui paha ka hopena maikaʻi ʻole i ka ʻai ʻana o ka meaʻai. ʻO Tributyrin kahi molekala paʻa maoli e hiki ke hele ma waena o ke ala gastrointestinal kiʻekiʻe a hiki i ka wā e ʻoki ʻia ai e ka lipase i loko o ka ʻōpū. ʻAʻole hoʻi ia he volatile i ka mahana o ka lumi, no laila ʻaʻole ia i uhi ʻia. Hoʻohana pinepine ʻo Tributyrin i ka silica dioxide inert ma ke ʻano he mea lawe. He porous ka silica dioxide a ʻaʻole paha e hoʻokuʻu piha i ka tributyrin i ka wā o ka ʻai ʻana. Loaʻa iā Tributyrin kahi kaomi mahu kiʻekiʻe e hoʻoulu ai i ka volatile i ka wā e hoʻomehana ʻia ai. No laila, paipai mākou e hoʻohana ʻia ʻo tributyrin ma ke ʻano emulsified a i ʻole ma ke ʻano pale.