He aha nā hopena o nā ʻakika organik a me nā glycerides acidified i "ke kū'ē i pāpā ʻia a hoʻemi ʻia ke kū'ē"?
Mai ka pāpā ʻana o ʻEulopa i nā mea hoʻolaha ulu lāʻau antibiotic (AGPs) ma 2006, ua lilo ka hoʻohana ʻana i nā waikawa organik i ka meaʻai holoholona i mea nui i ka ʻoihana hānai. ʻO kā lākou hopena maikaʻi i ka maikaʻi o ka hānai a me ka hana holoholona ua puni i nā makahiki he mau makahiki, ʻoiai lākou e hoʻonui nui nei i ka manaʻo o ka ʻoihana hānai.
He aha nā ʻakika organik?
ʻO nā waikawa organik" e pili ana i nā ʻakika a pau i kapa ʻia ʻo carboxylic acid i kūkulu ʻia ma luna o ka iwi kalapona e hiki ke hoʻololi i ke ʻano physiological o ka maʻi bacteria, e hoʻoulu ai i nā mea kūlohelohe e pale ai i ka hoʻonui ʻana a alakaʻi i ka make.
Aneane pau loa nā ʻakika organik i hoʻohana ʻia i ka meaʻai holoholona (e like me ka formic acid, propionic acid, lactic acid, acetic acid, sorbic acid a citric acid) he hale aliphatic a he kumu ikehu no nā cell. He ʻokoʻa,
ʻakika benzoickūkulu ʻia ma luna o nā apo ʻala a loaʻa iā ia nā ʻano metabolic a me ka absorption.
Hiki ke hoʻonui i ke kaumaha o ke kino, hoʻomaikaʻi i ka hoʻololi ʻana i nā meaʻai a hoʻemi i ka noho ʻana o nā pathogens i loko o ka ʻōpū.
1, hoʻemi i ka waiwai pH a me ka hiki ke hoʻopaʻa i ka hānai a me nā hopena antibacterial a me nā antifungal.
2, ma ka hoʻokuʻu ʻana i nā ion hydrogen i loko o ka ʻōpū e hōʻemi i ka waiwai pH, a laila hoʻāla i ka pepsinogen e hana i ka pepsin a hoʻomaikaʻi i ka digestibility protein;
3. Ka pale ʻana i nā hua bacteria gram-negative i loko o ka ʻōpū ʻōpū.
4, nā metabolites waena - hoʻohana ʻia e like me ka ikehu.
ʻO ka maikaʻi o kahi waikawa organik i ke kāohi ʻana i ka ulu ʻana o ka microbial e pili ana i kāna waiwai pKa, e wehewehe ana i ka pH o ka waika ma 50% ma kona ʻano dissociated a me ka wehe ʻole. ʻO ka hope ke ala e loaʻa ai i nā waikawa organik nā waiwai antimicrobial. Aia wale nō i ka loaʻa ʻana o nā waikawa organik i ko lākou ʻano unssociated hiki iā lākou ke hele i loko o nā paia o ka bacteria a me nā haʻani a hoʻololi i kā lākou metabolism i loaʻa iā lākou nā mana antimicrobial. No laila, ʻoi aku ka kiʻekiʻe o ka antimicrobial efficacy o nā waikawa organik ma lalo o nā kūlana acidic (e like me ka ʻōpū) a hoʻemi ʻia i ka pH neutral (i loko o ka ʻōpū).
No laila, ʻoi aku ka maikaʻi o nā ʻakika organik me nā waiwai pKa kiʻekiʻe a ʻoi aku ka maikaʻi o nā antimicrobials i loko o ka hānai ma muli o ke kiʻekiʻe kiʻekiʻe o nā ʻano i hoʻokaʻawale ʻole ʻia i loko o ka hānai, hiki ke pale aku i ka hānai mai nā haʻiki a me nā microorganism.
Acidified glyceride
I ka makahiki 1980, ua ʻike ka ʻepekema ʻAmelika ʻo Agre i kahi protein membrane cell i kapa ʻia ʻo aquaporin. ʻO ka loaʻa ʻana o nā kahawai wai e wehe i kahi wahi noiʻi hou. I kēia manawa, ua ʻike ka poʻe ʻepekema he nui nā aquaporin i nā holoholona, nā mea kanu a me nā microorganism.
Ma o ka synthesis o propionic acid a me butyric acid a me glycerol, α-monopropionic acid glycerol ester, α-monobutyric acid glycerol ester, ma ka pale ʻana i ka maʻi bacteria a me ka fungi glycerol channel, keʻakeʻa i ko lākou ikehu koena a me ka membrane dynamic balance, no laila e nalowale lākou i nā kumu ikehu, poloka ikehu synthesis i mea e pāʻani ai i ka lāʻau maikaʻi, a me ka bactericidal hopena maikaʻi.
ʻO ka waiwai pKa o nā waikawa organik ko lākou hopena pale i nā microorganism. ʻO ka hana o nā waikawa organik ke hilinaʻi maʻamau, a ʻoi aku ka nui o ka mea hana i hiki i ke kahua o ka hana, ʻoi aku ka kiʻekiʻe o ka hana e pono ai. He mea maikaʻi kēia no ka mālama ʻana i ka meaʻai a no ka meaʻai a me nā hopena olakino i nā holoholona. Inā loaʻa nā ʻakika ikaika, hiki i ka paʻakai o nā waikawa organik ke kōkua i ka hōʻemi ʻana i ka hiki ke hoʻopaʻa ʻia o ka meaʻai a hiki ke hāʻawi i nā anion no ka hana ʻana i nā waikawa organik.
ʻO nā glycerides acidified me kahi hanana kūikawā, α-monopropionate a me α-monobutyric glycerides, loaʻa ka hopena bactericidal kupaianaha ma Salmonella, Escherichia coli a me nā huakini gram-negative a me clostridium ma ke kāohi ʻana i ke kahawai wai-glycerine o ka bacteria, a ʻaʻole i kaupalena ʻia kēia hopena bactericidal e ka waiwai pKa a me ka waiwai PH; ʻAʻole wale ia i ka hana i loko o ka ʻōpū, akā ua komo pololei kēia glyceride momona momona i loko o ke koko ma o ka ʻōpū, a hiki i nā ʻāpana like ʻole o ke kino ma o ka vein portal e pale maikaʻi a kāohi i ka maʻi bacterial systemic.
Ka manawa hoʻouna: ʻAukake-22-2024 
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